Eric is often a goof, but he's right here. ETH has no choice but to attempt to UASF (user activated soft fork) to circumvent the OFAC compliant validators. As Eric points out, Ethereum nodes are very difficult to run. In order to successfully do this, people using ETH will either need to
a) run their own node
b) find someone that is running a OFAC noncompliant node and sync to them
In either case you're going to need some technical chops. You either need to repoint all of your services to this OFAC non-compliant node, or figure out how to run and maintain your own. Its not like you can just download Bitcoin core on an old laptop like BTC can. You are also going to have to deal with regulators going after non-compliant node runners if they choose to do so.
It is -very- unlikely that any exchanges will support this in the west. So you'll struggle to cash out to USD. The only way I can see that happening is if the UASF branch is overwhelmingly popular. It -could- go that way, I guess we'll see.
On another note, he talks a lot about "Bitcoin Maxi's" laughing at them.. which is true to some degree. However the greater point here is that they've been trying to tell ETH people how vulnerable their system is for a very long time and in return get nothing but hate and vitriol. ETH is heavily centralized in a number of critical ways which is why it is vulnerable to this situation. Its going to be even MORE vulnerable under PoS. Why? Because institutions hold a very large % of the total ETH supply, specifically exchanges. They will be the biggest stakers, and they will be OFAC compliant in the majority of cases. Proof of Stake is a system where the actors with the most capital make the rules. Its a stupid system that wasn't thought out properly and the people supporting it will get what they deserve.
At the end of the day ETH holders are beholden to whatever Vitalik and company decide is right. They are vulnerable to being targeted by government obviously. Good luck