
The only thing really like a Point of No Return is when you finish the last boss in Farum Azul. It closes down (changes) the capitol area and ends a lot of the NPC quests, though most of the major ones are still available to complete like Ranni and the Millicent Needle one. You can pretty much do anything, dungeon or boss wise, outside of the capitol that you left undone until you choose to advance to New Game. The things you REALLY want to knock out before the last boss are getting the required gear to make the fight more tenable, which is going to be certain weapons based on your build and things that protect you from the elements the boss uses. Maybe a good spirit ash if you are trying to solo it (Tiche and Poop Man are the best). All the completionist shit can be postponed. And believe me there is a lot of stuff in this game. I am on my 6th play and I am still finding shit I did not know existed.
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