I did some reading up on the PicoBrew system. For me there is one major question mark with the machine that hasn't be answered to my (or many other homebrewers) satisfaction, and that is how does it get rid of the DMS. This machine doesn't boil the wort and has a max temp of 206 degrees. One of the main purposes for boiling the wort is to drive out DMS. They really haven't answered how the PicoBrew gets ride of DMS other than saying "don't worry about it, we've addressed it and DMS isn't a problem with our system" but they never really elaborate. Conventional brewing wisdom says that with their machine DMS will be a major issue.
I am also a little skeptical of the cleaning aspect of it. They make it sound super simple but any homebrewer with a RIMS tube knows that just running some water and every couple a brews some cleaner through their system just won't cut it. If you can't break down the system for a thorough inspection and cleaning of all parts exposed to the ingredients and wort, I can cleanliness being an issue over time.
Also since this is basically a single infusion/no sparge system efficiency is going to suffer (they claim 50%-65% range). Not something that will stop you from making good beer but will force you to adjust recipes accordingly and to buy more grain.
Lastly since it only does 2.5gallon batches, for me personally I don't think it would save any time over my normal brew-day as I would have to basically brew twice to fill up my keg (although it would be less labor). That problem can be solved pretty easily by buying smaller kegs and/or bottling, but it is a limiting factor. Again, this is just for me personally, I know plenty of homebrewers who love doing small batches.