So the Roccat Tyon came in thursday and i've been using it exclusively since. I like it. I like it alot.
I can see having huge hands would be a problem because there are buttons everywhere, but physically it's the same length, maybe slightly taller and wider than my old Logitech M500. The thumb buttons are in a great position and i can hit all of them easily without fat thumbing. The top center fin is a 2 position button (left/right swipe) but nestled as far back as between the webbing of my thumb and the first knuckle is not ideal. Easily ignored however. The RGB lights have a nice color to them and are not too bright at all. It's a nice aesthetic coming from someone who generally hates stuff with lights.
The software...well, it obviously needs work which it's not getting. There are two software version you can get: the Driver and Swarm software. If you are considering this mouse at all STAY AWAY from the Swarm stuff. Don't even download it it's pure hot garbage. The base driver is all you need, and even it can be a little squirrely (more on that later). The configuration screen is well laid out and the button assignments are easily mapped if you don't like the default config (which is actually very decent). The thumb rocker is where you may encounter some trickery with assigning a single keystroke since it's an analog stick in truth that works on either an x or y axis as you assign it. It will take assigned macros however, and the macro editor has a ton of presets for older games. The ability to make new keypress macros works well.
From a hardware standpoint the mouse works a little differently than most mice and i believe it's due to the presence of the analog thumb button. And this is where the squirreliness of the driver comes in. By default Windows saw and installed the mouse instantly with generic drivers and all the default presets worked due to the presence of firmware on the mouse. When you make changes in the roccat driver and apply/okay it updates the firmware on the mouse. And....well it takes more than 10 seconds. Which sucks when you're testing things out. There are lots of reports of it locking up the application when attempting to do this. I personally haven't had an issue yet but then i've been patient to let it do it's thing before clicking anything else.
Would buy again.