Yeah, it's definitely 100% mcu. It will probably, if not more than likely be only within the Spiderman movies until needed.. Which will probably be Blade.
It'd be weird if they went straight spider-verse when the trailer is essentially leaving us off where spiderman ended. The poster showing off Spiderman with the graffiti "murderer."
I'd put money on this was part of the deal between Sony and Disney, is to joint venture with more movies.. They wanted Venom in the mcu but he wasn't. It's pretty much from here; how are they going to introduce venomverse to the mcu.
I feel with Leto frontmanning and after a history or atleast Joker.. Morbius will need the tie-in.