last i heard it takes place like, the day after avengers. no one has given any information on how that's possible, obviously, but there's been a few official-ish places that have stated that.
i'm having sort of a hard time being excited for this as well. i don't have the characters or the world, but i think it's time to start making the MCU much more loosely connected. they should still be in the same universe, but it's hard to have some rando mob boss mean anything when the hero just beat Cosmic Entity the Destroyer last week.