There's basically 4 types of chests in Cerobi: 1%, 2%, 5%, and 8%. Pretty much all the top-tier items are 1's or 2's, but there's almost always another no-respawn chest somewhere with the item in it (but it could be in Henne Mines optional area, the Great Crystal, or it could be just about at the end of the game). If you wanted more than one or don't want to wait, you either farm Cerobi, do something far worse like try to get a 1% drop or 3% steal, or do without.
I can't think of any Cerobi weapons worth the bother unless you need two Yagyu Darkblades for some reason. Armor is a different story entirely.
Yeah cleanse and the circlets are worth the effort. TK if you have not gone after Chaos, maybe. Everything else is better in Henne Mines with higher respawn. Pharos Basement has crappy reaspawn, but you can trigger chest pops simply by crossing the abundant doorways. The Pharos farm was by far the least tedious. Biggest cockblock is Excalibur being literally under Ultima, because by the time you can kill her you don't need it (Hellwyrm is likely already dead by this point). Assuming you have the multiple hunter classes, having another Yagu is worth it for Yaizmat, but farming the breaks and afking is less time consuming than getting a second one.