I still have never at any point actually finished Skyrim or Witcher 3. But I’ve thought about installing Skyrim again with mods.
Give it a try. Take it slow and test frequently, like after every few mods installed. I've had zero CTDs this playthrough by taking my time and carefully reading mod descriptions/install instructions. Use Mod Organizer 2.
Downgrade to 1.6.353. After the essential Unofficial Patch, I highly recommend the "simonrim" mods as a gameplay foundation to build around. Also, True Directional Gameplay, TrueHUD, and Precision by Ershin. And some of DeltaRider's. Then Open World Loot for a loot and encounter overhaul. Together these mods are like "vanilla +" as they freshen up the gameplay without going so far that it becomes ridiculous and unbalanced.
SKYUI, NordicUI + Nordic...ish + Compass Navigation Overhaul + Quick Loot RE for UI.
SMIM, Noble Skyrim, Granite Mountains, Realistic Water 2, and "Cathedral" mods for weather, environment, and landscapes. I don't use any tree mods as vanilla trees look just fine.
Lux, Lux Via, and Lux Orbis for interior/exterior lighting.
JKs Skyrim, Ryn's, and Arthmoor (on AFK mod site) for enhanced but balanced locations.
Unofficial HD Audio Project, The Northern Diaries, Immersive Sounds Compendium, and Audio Overhaul for Skyrim for audio.
AI Overhaul SSE
Conditional Expressions, EVG Animation Variance, Immersive interactions, and UNDERDOG's death animations.
powerofthree, wskeever, johnskyrim, and jayserpa have some great smaller gameplay/realism mods.
Lot of other smaller mods for realism and small gameplay tweaks.
Check for patches between mods. Follow
this guide to get leveled lists to work well together.
Run DynDOLOD at the end.