They did kill Gangplank.. /check lore page... oh he's alive again...
I was going to say, idk, they might be willing to kill off champs. They can exist in game as they were, and alt canon skins just fine.
yeah, people might lose a bit, if they see the stakes aren't there for main characters. when vander is WW, people are probably going to be way more annoyed then anything else.
If they did have the balls, Vi, Caitlyn and Jynx are all close to their full character arcs. Jynx might be rough, since shes become the mascot. Caitlyn however, is in danger. there is no GRAND lore element she needs to achieve to hit her league role. sheriff of Piltover. technically same with Vi. a 2 year time skip with them as a crime fighting dynamic duo would complete their arcs. Viktor has his glorious evolution, and cult he needs to start. Jayce needs to oppose that, and act as the lead versus noxxius, the void, magic wars, etc... the bigger threats of the world, that need Jayce, not Caitlyn or Vi to solve crimes or punch things. singed? maybe. is he required to do all his Noxxian war shit? probably not. that can all happen without him.
Echo is clearly not dying. Heirmerdinger isn't safe either.
a S2, could be again via and Caitlyn as buddy cops trying to keep peace. sus out corruption in Piltover, drawing the attention of Camilla. deal with zaun monsters, urgot/ww/singed, etc. demon or regular dude serial killer. Caitlyn could be killed by Camilla or Jhin.. and Vi thinks it was Jynx.