I liked the movie overall. It's hard to follow IW but it's easy to separate the two and just enjoy. Deadpool is almost its own genre really. It's a comic book, action, drama or something of that nature.
If I had to be picky, I thought some humor was a little forced. DP should be a BA when it comes to his profanity, gore, etc. and some of it was forced humor thought up by a junior high kid who just learned a few dirty words and think it makes him look big to say it around his friends.
Brolin is great but he isn't big enough for me. I guess you want someone with Brolin's acting chops with Kevin Nash's body and stature. I can deal but as a comic reader you just have a certain picture in your mind and when it pans to the group shot and Cable is the smallest guy of the bunch, it's a little off.
Domino was awesome. Humor was good in 95% of the places probably. Reynolds IS Deadpool. Colossus was a great. Hope to see Juggernaut again in addition to the X-Force. Overall, the movie did a lot of good for itself and it's future.