I'm going to presume it's same principals as airplane travel. Once you're in the air, there's pretty much nothing that you can interact with except weather and air pockets. Collisions between planes are almost non existent. The most dangerous aspects of flight are take off and landing: if you're going to have an accident, chances are its during those procedures. My uncle died in Mexico City when his plane landed on an incorrect runway in 1979. If you're afraid of flying, like me, just focus on the fact that you are very VERY unlikely to have some kind of catastrophic mechanical failure while in the air.
Now let's extrapolate that to space travel. Once you're in space, there's very little to interact with, even less than airplane travel. Space is largely empty...that's why it's called space.
Why everyone thinks space travel is dangerous, when in reality, it's far more vast then you can imagine.
Ironically, the two space shuttle disasters, Challenger and Columbia, occurred during takeoff and reentry/landing respectively.
Even during the Apollo program, the only fatalities were from a test procedure for Apollo 1 caused by mechanical failure that started a fire.
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