Starting to actually get some payouts from delirium finally. It's not ideal, but you really have to just go max zoom-zoom and ignore all loot until it's done.
So much of the danger in it tied up in death effects that stopping for even a second to try and grab something is just gonna get you killed. If you're just always going forward this means you also are mostly free to just step on every little pustule thingy to spawn more mobs, even if they are the suicide bombers guys cause they won't catch up to you.
There's also the fact that map bosses drop 2 splinters every time, so if you just blitzkrieg the entire map, collect your tier 5-6 reward or whatever, then slam the boss for a couple splinters you actually make some okay profit.
That all said having to walk back through the remains of the map to finish clearing and grab loot is some real garbage, but I don't really see a way to fix it given the nature of this mechanic.