Finished Leon A last night. Think I'm going to replay it and see if I can get a S rank for the infinite ammo pistol and get all the raccoon statues I missed the first go around. After that though, is there a proper order to doing the story modes? Beating Leon A opened up Claire B but I havent played through Claire A yet. Should I just jump into B or do Claire A first? Does it even matter from a story standpoint?
Here's the differences and similarities between Leon A and Claire A (a few spoilers below but nothing that spoils the major plot points). Since you played Leon already I'm mostly hiding the Claire spoilers. If you really want to avoid spoilers, I put a TL;DR at the bottom to just say my opinion of what you should do next. If you want a more detailed breakdown, read below.
- Same short run to the police station for both characters.
- Same police station puzzles but different keys let you in different rooms for Leon or Claire, and they get different weapons.
- Leon never gets the Heart Key and Claire never gets the Crank and the Club Key so don't go crazy looking for them like me!
- Same first boss fight.
- Different plot points in the parking lot, different enemies in the area (Lickers for Claire, Cerberus for Leon)
- Different ways to get the electric parts for different plot reasons for Claire and Leon.
At this point the stories diverge greatly for a bit :
- Leon goes to Kendo Gun Shop with Ada followed by Giant Gator sequence.
- Claire's sidekick character has a gameplay sequence in another exclusive area versus the exclusive plot character for Claire.
- Claire has quite a walk in the Raccoon streets, Leon never has that part.
- Once Claire joins with her sidekick character again, Mr. X stops showing up for Claire but will keep coming after Leon the whole game.
- Leon's sidekick character has an exclusive gameplay sequence.
The stories then become very similar again :
- After the initial sewer part exclusive to Leon, both characters have the same chess plug puzzle and sewer areas.
- Leon gets the flamethrower and Claire gets the electric rifle in the king/queen puzzle room.
- Both characters fight the same boss (with the crane and container)
- Both characters take the cable car to NEST.
- NEST is almost entirely the same for both characters except exclusive plot related to the sidekick characters and exclusive cinematics.
- Same boss fight after you reach the objective (getting the virus sample for Leon and something else for Claire)
The stories diverge again at this point :
- Self-destruct sequence activates, Leon has an exclusive boss fight before the end, and Claire has another.
- Same ending, and same post-credits stinger.
The B run for either Leon or Claire changes the following :
- Different way to reach the police station, you get different weapons at the very start on either character, and there are more enemies.
- The police station is much shorter, only really requires you do the 3 statue puzzle.
- Mr. X is already active in the police station right from the start but only triggers if you go near the STARS office, make sure you avoid that until you're ready for him.
- After that, the whole game goes exactly like the A run for either character until the very end.
- You get an extra boss at the very end, it's the same on both characters.
- You get the true ending cinematic.
TL;DR : Enough differences in Leon and Claire stories to play both, I recommend playing one character A and the other B since the main plot points and all exclusive cinematics are in both A and B runs for both characters, plus you get the extra final boss and the true ending that way. If Mr. X puts you on edge, you get a lot less of him in the Claire runs, but the downside is she never gets the flamethrower so the plant-zombies are more annoying to kill permanently (basically takes a flame grenade once they're down, while Leon can kill ALL the plant-zombies in the whole NEST with a single 200 fuel canister if you use it properly (short bursts

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