We aren't that far away from the point as a species where a single individual could probably wipe out all life on the planet, intentionally (terrorist) or unintentionally (accident). Bioweapons that infect and kill everyone, replicating nanomachines that turn all organic matter into grey goo, a zero point explosion that destroys the planet and/or solar system, etc. Its not unreasonable to assume every intelligent species approaches that point and the 0.000001% of the population that happens to be homicidal, sociopathic, and highly intelligent wipes out the species, especially if the technologies involved -- biotech, nanotech, infinite energy sources -- are stepping stones to AI and space travel.
I believe its part of the Great Filter response to the Fermi Paradox, that something occurs in every civilizations ascent that wipes it out.
Great Filter - Wikipedia
Otherwise at SOME point some society would have evolved some sort of nanotech self reproducing von neumann machines that simply go out and seed the entire galaxy with something, it would take less than 1m years to "visit" every star system with something that replicates, whether its their version of Wikipedia, MTV, or killer terminator 2 skynets. Of course its possible something is "protecting" new civilizations from being contacted/exterminated and does it so well there is no way to know if thats happening, or that something has visited our solar system and we just haven't discovered it (The Expanse).
That sort of falls to me though under the idea that reality is a simulation so perfect there is no way to know we live in a simulation. All our experience says that everything screws up eventually, nothing is perfect, and its much more likely that a screw up will manifest itself somehow, someday rather than simulations or guardians doing their job perfectly for eternity.