Health Problems

You guys are too hardcore for me. Just gonna be enjoying a bowl over here.

Well I don't think actual clinical serotonin syndrome is seen very much in any combination, regardless of the interactions or various classes of drugs involved (outside of MDMA and people abusing drugs combined with heavy SSRIs)

But I still wouldn't pop 150mg-200mg of tramadol and go hit 5-6 dabs every day while popping Tramadol like candy and smashing the bong inbetween, as inhibiting 5HT-1 is going to cause some cumulative buildup. The warning I gave stemmed from the relative unknowns that come with marijuana use itself that vary from person to person. I'd bank on sub-clinical serotonin syndrome without a lot of effort with Tramadol involved. We're talking more of an annoyance than health risk. Some vision things, some hot ears and hot head which is obnoxious, etc.

I would never say never with 5HT-1 inhibition involved and that is why I had to speak up about your absolute

Seems extreme. Three days should be plenty for aspirin to clear your blood. PLENTY.

Well this is happening now. This is from last night and this morning I now have welts on my legs and my back feels worse. I have no clue wtf is going on. Put in a call to my VNA and she's calling my doctors. A trip to Boston isn't really an option. Kind of freaking out.

Yikes dude. Those scratches during your sleep or something?

They're from me scratching. It's that damn bad. I didn't realize I had hives and shit so I've stopped scratching since we found out what's going on. Shit is driving me insane.

My brother in law just got hives when he found out he was allergic to amoxicillin

Back from the doctors. I've got some steroid cream and some Claritin pills. Everyone seems to think it's reaction to the Tramadol so I've stopped taking that. Now I'm going to bed and not getting up unless I've gotta take a dump until tomorrow. Fuck this shit!

And unfortunately benadryl won't do very much once the hives are formed. You need steroids for that, which you have. Benadryl works best if you can get it as you feel them starting to form.

Which, overnight in your sleep, ain't gonna happen.

Benadryl is more prophylactic. But you already phylacted. It'll stop them getting bigger, at least. But to reduce them... Its not how it works.

Trunk + Legs typical of a drug rash as a_skeleton_03 indicated.

One of the prime metabolites of Tramadol is known to cause some issues for some. The O-Desmethyltramadol, or simply O-DT.

A wheel reaction, a type of histamine release from an opioid, is not special. So a rash from itching, or being made to itch by an opioid or opiate is not uncommon. But naturally the majority of people have manageable itching while using any of these opioids available on the market. Certain opioids have a higher potential for a wheel response, which creates a large release of histamine all over your body. This response would be every time you take it. A wheel reaction isn't to be confused to an IGE antibody mediated allergic reaction, which presents as a "drug rash".

Its not clear from what you've given me whether this is an aggressive wheel response with some mild pre-existing contact dermatitis involved, or a predominantly a standalone IGE mediated reaction which is a little more "serious", but will resolve in a few weeks once you stop taking the drug and wait the period of time necessary for the antibodies its produced against this drug to go away.

A wheel reaction will clear up in a matter of days if you STOP itching. So you will be able to tell if its a drug rash or a really aggressive wheel reaction (IF YOU STOP ITCHING IT) by whether it clears up fast or not. Many people will ignore a strong wheel reaction and keep taking the medication, in this circumstance I'm leaning heavily towards an IGE mediated reaction so even if you were a knucklehead-- Its time to stop taking the medication as continuing to spike IGE mediated reactions can only produce bad things.

The hospital will probably be right that Tramadol is the cause. And I'm looking forward to congratulating you on your first drug allergy in a week from now when you are able to report back in.

Histamine-releasing and allergenic properties of opioid analgesic drugs: resolving the two. - PubMed - NCBI

Just had my drain removed. Thing was barely draining anything since I got out. Maybe 5-10cc per day total.
And the rash and hives are rapidly clearing after stopping the tramadol and using the cream they gave me. What a cluster fuck.
Hopefully clear sailing going forward.

After Xrays/PT/MRI and specialists I now know my back pain is moderate to severe bilateral neural foraminal stenosis L5-S1 and lumbosacral spondylolisthesis in the L5 and mild to moderate in 3 others( L2 L3 and T8 ). Explains all the burning pain I have in my feet and why it only appeared a year ago and is progressively getting worse. Decompression surgery may help as them putting cement into some other places but doesn't sound hopeful for the nerve pain/back pain. This is in addition to the thrombosis/swelling of upper extremity and heart failure. It'll be 2 more weeks before I meet with the specialist to see if and what surgeries are suggested or pain management direction from current.

I do know I've known 3 people who has had the cement put into their backs/back surgery and in all 3 cases they were worse off than before and 2 of those are now dead. It can easily be argued their death was other causes but in both they blamed it for the worsening condition by lack of mobility and quality of life.

Dad's in the hospital for a foot infection...again. Doesn't take care of himself, to busy taking care of everybody else, like he's got martyrdom syndrome.


My family is a fucking mess.