I actually watched episode 1 and 2 the wrong way around and didn't realise, this works as stand alone episodes like classic trek did.
It's pretty fucking good, I am STUNNED that they did the transgender episode just right, bringing up a lot of the issues on both sides of the argument for you to think about and resolving it with the status quo allows you to make your own mind up rather than the show telling you what is right. Given that it's Seth fucking McFarlane and anti transgender is equated with being a nazi nowadays in liberal hollywood, I just can't belive they pulled it off.
Episode 4 is a perfect episode of Star Trek, I can't wait to watch episode 5. Funny that the last episode of Dr Who was a similar concept, they had forced humour and everyone died at the end so the tone was off, and it was part of the season's story arc with major characters shoehorned in who did nothing... nice that The Orville gave one idea time to breathe and only used humour when it was appropriate rather than a gag a minute.