Fact: Gender Dysphoria is a real, mental illness (or condition / problem etc.)
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Transsexualism (ICD-10),[1] or gender identity disorder (DSM-IV),[2] is a condition in which a person's gender identity - the sense of being a man or a woman - contradicts his or her bodily sex characteristics. The individual experiences gender dysphoria and desires to live and be accepted as a member of the opposite sex.
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Gender dysphoria is a discomfiting mental state associated with a disparity between one's internal sense of being either male or female and one's external anatomical sexual characteristics. Because most persons have never experienced such a disparity, perhaps one could empathize by imagining what it would be like for a man to wake up one morning to discover that his penis was gone. Further, imagine that it had been replaced by a vagina, with enlarged breasts on the chest. Surely, the man would feel extremely uncomfortable; manifesting a strong desire to change his body; a desire that is far more intense than a simple cosmetic desire. One could similarly imagine the inverse scenario for a woman. Such intense discomfort, accompanied by a desire for change, is the hallmark of gender dysphoria.
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The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)1 defines gender dysphoria (GD) as a condition in which a person has marked incongruence between the expressed or experienced gender and the biological sex at birth. This causes clinically significant distress or impairment in social, occupational or other important areas of functioning. Individuals with GD experience a strong desire to be treated as the other gender (or some alternative gender different from their assigned gender) and/or to be rid of their sex characteristics, and/or the strong conviction of having feelings and reactions typical of the other gender (or some alternative gender).
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Gender dysphoria (GD) represents a condition where a person's gender assigned at birth and the gender with which they identify themselves are incongruent. Hence, these individuals can be very uncomfortable with their biological sex, primary and secondary sex characteristics, and social gender roles and they experience various levels of distress.
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This paper is heavily focused on trans voice, but still states:
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Gender dysphoria (also known as “transsexualism”) is characterized as a discrepancy between anatomical sex and gender identity. Research points towards neurobiological influences."