My setup was 2 main frames, Protea and Voruna.
I had 2 Protea builds, the standard camping setup for missions like survival, defense, interception and so on with just a ton of duration and power and 4 replaced with Roar for nice support(+shield orb+dispenser so very useful in party). Second build kept the original 4 but with the augment that makes a turret stick to your frame, for movement maps. Bit tedious to use as you have to cancel and recast the ult before it wears off otherwise it warps you back to fucking Narnia but it's otherwise an extremely fast setup(with Praedos and Amalgam Serration for a bunch of speed since Protea isn't fast baseline). Protea can do all content with these 2 builds and had no issue with stuff like level cap steel path circuit for farming, Deep Archimedea Elite with no weapon and was fine for daily bounties too, great for Railjack(dispenser gives you infinite energy so you spam heat seeking missiles). The only weakness is toxic damage and since in 1999 they nerfed the stupid ancient toxic mobs it shouldn't be much of a problem.
Voruna was played as a melee frame, replaced 4 with Gloom for added survivability against everything, very hard to kill, high mobility baseline(speed on invis, parkour passive, incarnon melee weap all give additional parkour, amalgam serration again for more sprint). Very fun fast frame, pretty good damage, infinite energy via equilibrium+very tanky via arcane blessing+adaptation+gloom healing. I only turned Gloom on when needed though and often it was off the entire time so can be replaced with anything else but it made stuff like Necramechs in Sanctum safe as long as they don't one shot you while without it feels iffy at times when fighting strong individual mobs. I also had a 2nd Voruna nuke build with her Prey of Dinar augment where you just massively spread status and instantly kill everything, great for high density maps like SP survival stuff but shit elsewhere.
After that I used a few more frames regularly, Titania for speedrun shit, Wukong with the autohack subsume for Spy/Rescue, Ivara for farming Riven shit(Loki for the wall latching ones), Mesa for open world bounties(don't have to aim just spin and shoot), Sarin for EDA grind for focus but I only did that for a week before I felt like killing myself and just grinded it doing normal content after. Dante/Jade for when I felt like doing something different or for SP circuit since they didn't need weaps(Titania there too). I had several more frames I'd use when bored but nothing really often.
