I went from just shy of 290 pounds to 185 and didn't take any supplements (other than food) at all for exercise during that time. When I started trying to put on some muscle, I did some research and started using protein powder. Around the middle of '12, I started experimenting with some other stuff (green tea, creatine, cla's, nos, different proteins). Most of it was junk, but I did feel like the creatine and nos added enough to warrant the expense. I liked White Flood when I tried it, but my local shop doesn't have it and I get the C4 for about the same cost.