My group hated Descent, the one player vs everyone else aspect always left one side feeling like the game was a bunch of crap. Either the DM won and all the players went "Well yeah, your powers are cheaty as fuck and that was 0 fun", or the players won and went "Well, yeah, we won, but barely because your powers are cheaty as fuck." and the Dm feels shitty. There's an app now that takes on the role of bad guy so you can all play together. I haven't tried it yet, but I hear good things, and I love the Mansions of Madness second edition one (which I think is close to the same thing). The app is free as well I believe, at least for a base campaign. Something worth looking into maybe? Find a youtube video and see if it fills your need.
As far as some of the other suggestions-
Gloomhaven, Your best option... but good luck finding it.
KDM, This is for when you already have a board game wall with thousands of dollars worth of games, not a first game.
Shadows of Brimstone, Awesome concept, but poorly executed game. Lots of wonky rules and easy to abuse mechanics.
Pathfinder Card game, Pretty fun little game, but can be very random feeling, and its all card based.
Zombiecide, Not the worst game, but not very good either. Doesn't really fulfill any campaign mode either, your chars start over every game.
Thunderstone, Not in print anymore, so Cost is $$$, plus again, its a card game, so no dice if you were hoping for any mini combat.
That's my shit take on all the games mentioned.