I'm curious if people can make 1-2-2 or (although worse tactically) 2-1-2. Supports can get nearly the same, if not more, gold than tank/initiator junglers. So run your second support mid, have one or both supports take smite. Feed each buff at the beginning to your lanes and take extra jungle gold as you go. Your mid support can roam or you can just have lots of mid-lane pushing and dragon control, plus invade their bottom buff pretty aggressively on respawn. You'll have way more ward coverage mid (normally the hardest lane to ward thoroughly) and the gold difference will only stack up vs. a farming jungler as far as I can tell from watching people play it today.
Obviously this is purely theorycraft based on early observation of people playing around, but it sure looks like at least a viable niche strat.
Edit: Forgot I was gonna talk about supports again. Someone did math on all the support changes, and most of the nerfed supports surpass their old numbers at or before 200 AP (usually equals out around 100-150, better after that). The problem is, the actual support characters are not going to get that much AP. Watching the WePlay tourney today (which is 3.14), every support builds the new Reverie, with a Sightstone, tier 2 boots mixed in. Support characters have terrible AP scaling, and so get more benefit from building more support-style items (or tank items for Leona/Thresh/Blitz/Taric/Ali). So essentially, most supports are never going to have enough AP to get back to their old values. The ones that build straight AP will surpass their old values by a fairly timid amount and overall contribute less than a support that does not build AP.
So it's not that support champs won't be picked, it's just do you want your team to have a second AP carry? Pick a mage. Want utility? Pick support. While that's fine in theory, it also removes any item choices from support characters that aren't just traps.
Also, the new talisman of ascension just seems too much better than the other 2. I want to see the other ones used but haven't in these tourney matches so far.
Double Edit: Looks like this Zyra went for the 50 AP support item, woo!