Another part of why Natives were more susceptible to disease was because the population which inhabited the Americas was a subset of a subset of a subset of a subset of the overall human genome. This genetic bottleneck from early inhabitation of the Americas left a homogenized genome, which reduced the overall population's ability to adapt and resist new changes to their environment, like the introduction of new pathogens.
There was simply less overall genome diversity for the population to work with to resist the impacts of the disease.
There was simply less overall genome diversity for the population to work with to resist the impacts of the disease.
- 1