Weight Loss Thread

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Animosity

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Can someone explain to me the benefit of these drugs vs just intermittent fasting?
They arent even remotely the same thing. All intermittent fast is is eating during a feeding window. You still eat the normal amount of food. The drug makes it so you dont even feel hungry. And when you do eat you dont eat much as it makes you feel full. Essentially puts you into a huge calorie deficit.

You can mitigate muscle loss if you lift weights and when you do eat, eat mostly from protein.
 

Khane

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I haven't seen any evidence of the drugs themselves forcing the body into some strange/different metabolic state where it starts cannibalizing muscle even if it can find energy sources elsewhere. The drugs simply change people's consumption and habits and sometimes those changes are so drastic and they aren't eating enough protein that the body just does what it normally does in periods of extreme calorie and protein deficits.

The drugs, aside from their prescribed use to help with type 2 diabetes, are essentially drugs of affluence right now because of how expensive they are for secondary prescribed use (weight loss). This gives the drugs a massive stigma, understandably so.

And even if people go on and off of them forever to help maintain... if there are no major, attributable risks, and they can afford it... what the fuck is the problem? People get so weird about OTHER people losing weight.
 

Gurgeh

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I haven't seen any evidence of the drugs themselves forcing the body into some strange/different metabolic state where it starts cannibalizing muscle even if it can find energy sources elsewhere. The drugs simply change people's consumption and habits and sometimes those changes are so drastic and they aren't eating enough protein that the body just does what it normally does in periods of extreme calorie and protein deficits.

The drugs, aside from their prescribed use to help with type 2 diabetes, are essentially drugs of affluence right now because of how expensive they are for secondary prescribed use (weight loss). This gives the drugs a massive stigma, understandably so.

And even if people go on and off of them forever to help maintain... if there are no major, attributable risks, and they can afford it... what the fuck is the problem? People get so weird about OTHER people losing weight.
Yeah sorry to be skeptic of the pharmaceutical industry in 2025. Especialy when it comes to a lifelong, expensive, relatively new treatment.

Reminds me a lot of ppi and statins.
 
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Kirun

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All intermittent fast is is eating during a feeding window. You still eat the normal amount of food. The drug makes it so you dont even feel hungry. And when you do eat you dont eat much as it makes you feel full. Essentially puts you into a huge calorie deficit.
Most people aren't eating 2,500-3,000 calories in a "feeding window". Most people fast for..wait for it...maintaining caloric deficits/intake.
 
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Khane

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Yeah sorry to be skeptic of the pharmaceutical industry in 2025. Especialy when it comes to a lifelong, expensive, relatively new treatment.

Reminds me a lot of ppi and statins.

I understand the skepticism wholeheartedly. And if someone doesn't want to inject themselves with a drug for weight loss.... I get it. And nobody should do that if they don't want to and are uncomfortable with any potential side effects, and there is always the potential for side effects.

The drugs have been around for a while though and have been approved by the FDA for almost a decade. Well semaglutide has been.
 

Animosity

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Most people aren't eating 2,500-3,000 calories in a "feeding window". Most people fast for..wait for it...maintaining caloric deficits/intake.
I understand that. You can still easily eat 2500 calories in an 8 hour window. But fasting still isnt the same as taking a drug. Fasting isnt some miracle hack.
 

BunkyChutt

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alot of people are doing IF these days. waking up at 5-6am and eating breakfast at 1-2pm. it allows for a short window of eating then what? 16 hours of fasting right? not for me.
 
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Palum

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I understand that. You can still easily eat 2500 calories in an 8 hour window. But fasting still isnt the same as taking a drug. Fasting isnt some miracle hack.

Right but like, isn't that what those drugs basically do? They just stop you from eating for periods?
 

Animosity

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Ah OK, in layman terms I had heard these basically just suppress hunger, didn't realize they hit the digestive system too.
They do but its not as simple as just not eating for a few hours. When you fast you are still hungry and want food. The drug makes you not even desire food or have an appetite. Completely different things going on here.
 
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ToeMissile

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Ah OK, in layman terms I had heard these basically just suppress hunger, didn't realize they hit the digestive system too.
I recall reading about some evidence that there is also some inhibition/moderation of addiction pathways. Khane Khane mentioned it about his aunt earlier.
 

Kirun

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They do but its not as simple as just not eating for a few hours. When you fast you are still hungry and want food. The drug makes you not even desire food or have an appetite. Completely different things going on here.

Learning to have the willpower to suppress hunger and stick to a regimented diet builds good eating habits/discipline.

These seem similar to lapband, gastric bypass, etc. in that they're a temporary solution until your poor discipline and eating habits take root again.
 
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Animosity

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Learning to have the willpower to suppress hunger and stick to a regimented diet builds good eating habits/discipline.

These seem similar to lapband, gastric bypass, etc. in that they're a temporary solution until your poor disciple and eating happens take root again.
Thats exactly what it is. Not arguing that!
 
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Cad

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Learning to have the willpower to suppress hunger and stick to a regimented diet builds good eating habits/discipline.

These seem similar to lapband, gastric bypass, etc. in that they're a temporary solution until your poor discipline and eating habits take root again.
Certainly true, but a lot of the lardasses that need this aren't going to suddenly find good eating habits/discipline. If they have to go on this for a while every couple years to keep under a 30BMI, that should be fine.

Are we really arguing for more fatties? Anything that helps my eyes from being seared by disgusting fat people everywhere is a good thing in my book.
 
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Gurgeh

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Learning to have the willpower to suppress hunger and stick to a regimented diet builds good eating habits/discipline.

These seem similar to lapband, gastric bypass, etc. in that they're a temporary solution until your poor discipline and eating habits take root again.
well maybe bad habbit can't come back as long as you take, but evidence is clear that you'll get the weight back if you stop. Hence why I called it a lifelong medication. It's certainly worth the risk in some cases, but even the average doctor says it should be left to diabetics and severely obese people.
 

Kirun

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Certainly true, but a lot of the lardasses that need this aren't going to suddenly find good eating habits/discipline. If they have to go on this for a while every couple years to keep under a 30BMI, that should be fine.

Are we really arguing for more fatties? Anything that helps my eyes from being seared by disgusting fat people everywhere is a good thing in my book.
Nope. If you're some 400 lb. land whale you're literally dying. So, this is definitely a better alternative than that.

I just know as a former landwhale that if I had access to shortcuts like these, it likely would've been a constant see-saw with my weight.

But this seems like a retarded thing to take if you're just staring at needing to lose 25-50lbs. or so. Considering possible side effects, the need for your body to possibly now be on the Big Pharma subscription plan, etc.
 
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Gurgeh

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Nope. If you're some 400 lb. land whale you're literally dying. So, this is definitely a better alternative than that.

I just know as a former landwhale that if I had access to shortcuts like these, it likely would've been a constant see-saw with my weight.

But this seems like a retarded thing to take if you're just staring at needing to lose 25-50lbs. or so. Considering possible side effects, the need for your body to possibly now be on the Big Pharma subscription plan, etc.
An issue I see, beside known/unknown side-effects is that you aren't a landwhale just because you eat too much. It's also a matter of eating shit and not exercising. These drugs will put a band-aid on the eating too much, and possibly somewhat hide the other 2 underlying problems, but certainly not solve them. This is a partial fix, especialy for people that want to look good in the mirror, and as you say lose 20 50 pounds. You'll look good in the mirror, but won't get any of the health benefits you'd have from going the regular route, and you're taking significant risks with the drug itself. Feels like cosmetic surgery.
 

Palum

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An issue I see, beside known/unknown side-effects is that you aren't a landwhale just because you eat too much. It's also a matter of eating shit and not exercising. These drugs will put a band-aid on the eating too much, and possibly somewhat hide the other 2 underlying problems, but certainly not solve them. This is a partial fix, especialy for people that want to look good in the mirror, and as you say lose 20 50 pounds. You'll look good in the mirror, but won't get any of the health benefits you'd have from going the regular route, and you're taking significant risks with the drug itself. Feels like cosmetic surgery.

Yea, people will cry about this because they always do but it's not just as simple as thermodynamics. It's also metabolism and other factors. The problem is burning calories is presumed rather than tested, while eating can actually be empirically measured. Everyone is using those fitbit things these days or whatever, and yea, great, so many thousand steps is better than zero. But there's a huge difference in energy usage depending on physical factors. Compare walking on a treadmill holding the rails vs. walking vs running vs walking on the job while physically engaged with activities (carrying boxes of stuff, etc.). Your body tends to adapt to minimal energy exertion for any given event. So you subconsciously learn to save calories because that's biologically important.

I know several people that have used these drugs, none of which are very active, and all failed to hit their target weight because even with vastly reduced caloric intake they just hit equilibrium with their basal metabolic rate. They essentially just adapted to sloth and averaged out.

I'm sure they are still the correct course of action in some cases, but I have yet to see these drugs work 'miracles', it's more just drug-induced bootstrapping.
 

ToeMissile

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An issue I see, beside known/unknown side-effects is that you aren't a landwhale just because you eat too much. It's also a matter of eating shit and not exercising. These drugs will put a band-aid on the eating too much, and possibly somewhat hide the other 2 underlying problems, but certainly not solve them. This is a partial fix, especialy for people that want to look good in the mirror, and as you say lose 20 50 pounds. You'll look good in the mirror, but won't get any of the health benefits you'd have from going the regular route, and you're taking significant risks with the drug itself. Feels like cosmetic surgery.
I don't think anyone is arguing these drugs match properly adjusting diet + exercise, etc. But society at large has come to a point where there are all these pressures, not to mention whatever predispositions someone may have that will affect their ability to maintain a healthy weight/life style. This isn't to say that people don't need to be responsible for themselves or that there aren't best practices that should be followed when using the drugs.

I'm curious if anyone has 'done the math' on funding X% of the population for one of these meds and how much it reduces strain on the healthcare systems due to dealing with all the other conditions brought on by obesity.
 
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